Acts & locations

Complete guide to all Acts in Slay the Spire 2, including regions, bosses, events, and monsters

How acts work

Ancient encounters
Each Act begins by meeting an Ancient which gives you the option to choose between a selection of 3 boons
Boss fights
Each Act ends with a fight against a Boss
Neow
Neow will always meet you at the start of Act 1 (with the exception of the very first run of a save game)
Alternate acts
The game features alternate Acts which are currently only implemented for Act 1, choosing randomly between Overgrowth and Underdocks
Unique content
Every Act has a unique selection of Events, Monsters, Elites, and Bosses

Act 1

At the start, player meets an Ancient to choose between 3 boons For Neow, act patrons, and blessing lists, see the Ancients page.

Overgrowth

One of two possible first Acts in Slay the Spire 2. The introductory act of the game.

Rooms: 15First three: Drawn from a pool of weaker enemies

Exclusive events

  • Aroma of Chaos
  • Byrdonis Nest
  • Dense Vegetation
  • Jungle Maze Adventure
  • Luminous Choir
  • Morphic Grove
  • Sapphire Seed
  • Tablet of Truth
  • Unrest Site
  • Wellspring
  • Whispering Hollow
  • Wood Carvings

Monsters

First three encounters (pool)

  • Nibbit

    A single Nibbit

  • Slimes

    1 random medium slime (Leaf Slime or Twig Slime) + 2 random small slimes

  • Shrinker Beetle

    A single Shrinker Beetle

  • Fuzzy Wurm Crawler

    A single Fuzzy Wurm Crawler

Remaining encounters

  • Inklets

    3 Inklets

  • Mawler

    A single Mawler

  • Nibbits

    2 Nibbits

  • Ruby Raiders

    3 randomly chosen from Axe Raider, Assassin Raider, Brute Raider, Crossbow Raider, and Tracker Raider

  • Slimes (Full)

    Twig Slime (M) + Leaf Slime (M) + Leaf Slime (S) + Twig Slime (S)

  • Flyconid + Slime

    1 Flyconid + 1 random medium slime

  • Snapping Jaxfruit + Flyconid

    1 Snapping Jaxfruit + 1 Flyconid

  • Fogmog

    A single Fogmog (can summon Eye With Teeth during combat)

  • Cubex Construct

    A single Cubex Construct

  • Vine Shambler

    A single Vine Shambler

  • Overgrowth Crawlers

    Shrinker Beetle + Fuzzy Wurm Crawler

  • Slithering Strangler + companion

    1 Slithering Strangler + one of: 1 Snapping Jaxfruit, 1 random medium slime, or 2 random small slimes

Boss pool

Each name links to the matching entry on the Boss encounters page (screenshots & notes).

Underdocks

The other possible Act 1 region, featuring underwater/dock aesthetics.

Boss pool

Each name links to the matching entry on the Boss encounters page (screenshots & notes).

Act 2

Hive

The second Act in Slay the Spire 2, featuring hive/beast-themed environment.

Boss pool

Each name links to the matching entry on the Boss encounters page (screenshots & notes).

Act 3

Glory

The final Act in Slay the Spire 2.

Boss pool

Each name links to the matching entry on the Boss encounters page (screenshots & notes).