Boss encounters

A complete compendium of Bosses in Slay the Spire 2, organized by Acts. During the initial days of Early Access, please take everything with an extra grain of salt.

Other encounter types

Bosses are only one slice of the climb—events, elites, and hallway fights all feed your deck before you reach these gates.

Overview

Each act pairs regions with a boss pool. Multi-image rows mark multi-phase fights (e.g. Lagavulin asleep vs awake, or Waterfall Giant / Test Subject sequences).

Act 1Overgrowth Bosses

Ceremonial Beast

Ceremonial Beast

Act 1 Overgrowth Boss

Kin Priest (Kin Follower)

Kin Priest (Kin Follower)

Act 1 Overgrowth Boss

Vantom

Vantom

Act 1 Overgrowth Boss

Act 1Underdocks Bosses

Lagavulin Matriarch (Asleep)

Lagavulin Matriarch (Asleep)

Act 1 Underdocks Boss - Sleeping state

Lagavulin Matriarch (Awake)

Lagavulin Matriarch (Awake)

Act 1 Underdocks Boss - Awake state

Soul Fysh

Soul Fysh

Act 1 Underdocks Boss

Waterfall Giant — image 1 of 3
Waterfall Giant — image 2 of 3
Waterfall Giant — image 3 of 3

Waterfall Giant

Act 1 Underdocks Boss - Multi-phase encounter

Act 2Hive Bosses

Kaiser Crab

Kaiser Crab

Act 2 Hive Boss

Knowledge Demon

Knowledge Demon

Act 2 Hive Boss

The Insatiable

The Insatiable

Act 2 Hive Boss

Act 3Glory Bosses

Doormaker (Door Form)

Doormaker (Door Form)

Act 3 Boss - Door transformation

Doormaker

Doormaker

Act 3 Boss

Queen

Queen

Act 3 Boss

Test Subject #C10 — image 1 of 3
Test Subject #C10 — image 2 of 3
Test Subject #C10 — image 3 of 3

Test Subject #C10

Act 3 Boss - Multi-phase encounter